ArticleFrontiers in nutrition2025
Metabolic adaptation fluctuates with different prediction equations: a secondary analysis based on a weight-loss clinical trial.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Metabolic adaption (MA) might be of clinical relevance in weight loss management. However, it is unclear whether resting metabolic rate (RMR) reduction in weight loss reflects true MA or fat free mass (FFM) loss. Methods: We re-analyzed the data based on a weight loss trial of 131 patients (aged 33.3 ± 6.7 years) with overweight/obesity. Anthropometric data, body composition, daily physical activity, sleep hour and dietary intake were collected for every 4 weeks (baseline, week 4, 8, 12, and 16). The linear mixed model was used to evaluate the absolute change in RMR and adjusted RMR [aRMR = RMR (kcal) divided by FFM (kg)] with two different equations (Katch-McArdle-determined vs. BIA-determined) for every 4 weeks after adjustment of age, sex, daily physical activity, sleep hours, dietary intake, and baseline FFM and fat mass (FM). Results: Following the 16-week intervention, a significant reduction was observed in body weight [β: -5.6 kg; 95% Confidence Interval (CI): -6.3 kg, -5.0 kg], BMI (β: -2.3 kg/m Conclusion: The use of different prediction equations might account for variations in MA in this study. The results highlight the importance of preserving FFM during weight loss, thus to prevent reductions in RMR.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.