Evidence map›Paper›PMID 40948862›Full record

ArticleFrontiers in nutrition2025

Breastfeeding duration and the risk of systemic juvenile idiopathic arthritis: a cross-sectional study.

Qiang Luo, Hui Zhang, Xinlin Wu, Xiaoqiong Wei, Xuemei Tang

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Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

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5 authors.

Qiang Luo *Department of Rheumatology and Immunology, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Hui Zhang *Department of Rheumatology and Immunology, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Xinlin WuDepartment of Rheumatology and Immunology, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Xiaoqiong WeiDepartment of Rheumatology and Immunology, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Xuemei TangDepartment of Rheumatology and Immunology, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.

Funding

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6 · The paper itself

Abstract

Background: Systemic juvenile idiopathic arthritis (sJIA) is an autoinflammatory subtype of JIA with distinct immunopathogenic mechanisms. Early-life nutritional exposures such as breastfeeding may influence immune development and inflammatory disease risk, yet evidence in sJIA remains limited. Therefore, this study aimed to examine the association between breastfeeding duration and the likelihood of developing sJIA versus non-sJIA, and to assess whether systemic inflammatory markers mediate this relationship. Methods: In this cross-sectional study, we included 450 children diagnosed with JIA from 2018 to 2024 at Children's Hospital of Chongqing Medical University. Breastfeeding duration was retrospectively collected, and patients were classified into sJIA and non-sJIA groups. Multivariable logistic regression and restricted cubic spline models were used to assess the association between breastfeeding duration and the risk of sJIA. Mediation analysis was conducted to quantify the indirect effects of inflammatory mediators on this association. Results: Among 450 patients with JIA, those with sJIA ( Conclusion: Shorter breastfeeding duration is associated with a higher probability of sJIA, and this relationship may be partially mediated by systemic inflammatory status. These findings highlight the potential role of early-life nutritional exposures in promoting autoinflammatory disease expression and support further prospective investigations.

Indexed as

breastfeeding durationjuvenile idiopathic arthritismediation analysisrestricted cubic spline modelssystemic juvenile idiopathic arthritis

Identifiers

PMID40948862
PMCPMC12426014

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