ArticleFrontiers in nutrition2025
Association of serum creatinine/cystatin C ratio with insulin resistance and all-cause mortality: a national cohort analysis.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Serum creatinine/cystatin C (Cr/CysC), a biomarker for skeletal muscle mass, has not been well studied in relation to insulin resistance (IR). This study examined the associations between Cr/CysC, IR, and all-cause mortality. Methods: Data were sourced from the NHANES database and analyzed using logistic and linear regression to assess the association between Cr/CysC and IR, quantified by the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL) ratio. Restricted cubic splines (RCS) were employed to identify non-linear associations, and Cox regression was leveraged to determine associations with all-cause mortality. Results: Higher Cr/CysC ratios were strongly associated with lower IR risk (OR = 0.48, 95% CI: 0.32-0.73, Conclusion: Cr/CysC is inversely associated with IR and all-cause mortality, suggesting its potential as a low-cost marker for stratifying IR risk.
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