ArticleGland surgery2025
Identification and validation of a novel lymph node metastasis-related model for papillary thyroid carcinoma to predict the prognosis.
Article in Gland surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Background: Papillary thyroid carcinoma (PTC) is a common malignancy with a good prognosis, but lymph node metastasis (LNM) is associated with a poor prognosis for patients. This study aimed to construct an LNM-related risk model and identify hub genes that could predict the prognosis of PTC. Methods: Gene expression and clinical information were obtained from The Cancer Genome Atlas (TCGA). Cox analysis was used to select hub genes and construct a risk model. The model was validated through receiver operator characteristic (ROC) curve. Nomogram was constructed for clinical application. Survival analysis was performed by the Kaplan-Meier (K-M) curve. Methylation of hub genes and drug sensitivity were calculated in Gene Set Cancer Analysis (GSCA). The expression levels of four hub genes and their effect on the malignant features of PTC were further validated through cell experiments. Results: A risk model was constructed by four hub genes Conclusions: We constructed an LNM-related risk model based on four hub genes, and targeting these key genes can benefit patients from immunotherapy or chemotherapy.
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