ReviewFrontiers in bioengineering and biotechnology2025
Functionalized metal-organic framework and MOF-derived materials for bone regeneration applications.
Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Metallic topological structures in bone repair implants: Design, properties, and biological interactions.Journal of orthopaedic translation · 2026Review
- Converging chemistry and clinical orthopedics in the emerging role of MOFs in advanced bone defect repair.Theranostics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone defects resulting from trauma, tumors, infections, and aging present significant clinical challenges, with conventional grafts hindered by limitations in biocompatibility, mechanical strength, and integration. Metal-organic frameworks (MOFs), as advanced nanomaterials with tunable porosity, high surface area, and stimuli-responsive properties, hold immense potential for bone regeneration. This review provides a comprehensive overview of the classification, synthesis methods, osteogenic mechanisms, and applications of functionalized MOFs and their derivatives in bone repair. MOFs are classified based on structural topology, chemical composition, and functional applications. Synthesis techniques, including solvothermal, ultrasonic, and electrochemical approaches, are evaluated for customizing physical properties such as pore architecture and stability. Osteogenic mechanisms encompass enhancing implant physical characteristics to promote cell adhesion, sustained release of metal ions to activate signaling pathways, controlled drug delivery for targeted therapy, and anti-inflammatory/antioxidant effects through reactive oxygen species scavenging. Applications address various bone pathologies, demonstrating improved angiogenesis, osteointegration, and antibacterial performance in preclinical studies. Key challenges, including cytotoxicity, long-term biosafety, and scalability, are discussed, alongside strategies like surface modification and hybrid composites to overcome these barriers. Future perspectives focus on developing smart MOF-based scaffolds for personalized regenerative medicine, underscoring their transformative potential in orthopedic therapies.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.