ReviewFrontiers in bioengineering and biotechnology2025
Tendon mechanobiology in the context of tendon biofabrication.
Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review.Advanced healthcare materials · 2026Review
- Aged Tendons Have Impaired Mechanosensitivity and Lower Thresholds for Injury under Dynamic Compression.bioRxiv : the preprint server for biology · 2026Article
- Advances in Achilles Tendon Tissue Engineering: Integrating Cells, Scaffolds, and Mechanical Loading for Functional Regeneration.Bioengineering (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tendons are often affected by injuries or tendinopathies, resulting in serious and long-lasting impairments. The repair capacity is very low with a high risk of rerupture. Nevertheless, early, moderate and intermittent functional training adapted to the healing process has been shown to support tendon healing. The mechanosensitive tenocytes are responsible for extracellular matrix (ECM) synthesis, a process that is highly dependent on their specific and local mechanotopographical niche. The mechanical stimuli are triggered by the surrounding ECM that are then recognized by the cells via mechanosensation, transduced via activated intracellular molecular cascades to initiate the mechanoresponse, a process known as mechanotransduction. Hereby, the activation of calcium (Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.