Evidence map›Paper›PMID 40949153›Full record

ReviewFrontiers in pharmacology2025

The potential of medicinal food plant

Meng Gao, Haijing Wang, Xiaojing Chen, Wensheng Wang, Yongmei Liu

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Ginsenosides fromJournal of ginseng research · 2026
    Review
  3. Journal of ginseng research · 2026
    Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Meng GaoNeck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Haijing WangQingdao Traditional Chinese Medicine Hospital, Qingdao Hiser Hospital Affiliated of Qingdao University, Qingdao, China.
Xiaojing ChenQingdao Haici Traditional Chinese Medicine Medical Group North Campus(Qingdao Hongdao People's Hospital), Qingdao, China.
Wensheng WangInstitute of Brain Science and Brain-Inspired Research, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Yongmei LiuNeck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Panax ginseng C.A. Mey. (PG), a well-documented medicinal food plant with generally recognized as safe status, exhibits therapeutic potential for managing metabolic disorders (type 2 diabetes mellitus (T2DM), obesity), inflammatory bowel diseases (IBD), and neurodegenerative conditions via modulation of the gut microbiota (GM). This systematic review of 102 studies reveals that ginsenosides (Rb1, Rg1, and Rg3) undergo biotransformation mediated by the GM into bioactive metabolites (e.g., compound K), enhancing their bioavailability by 3- to 5-fold (p < 0.01). Three core mechanisms were identified: 1) inhibition of the TLR4/NF-κB pathway reduces pro-inflammatory cytokine levels by 40%-60%; 2) upregulation of tight junction proteins (ZO-1/claudin-4) strengthens intestinal barrier function by 2.3-fold; and 3) selective GM modulation increases the relative abundance of probiotics (

Indexed as

gut microbiotamedicinal food plantPanax ginseng C. A. Mey.pharmacologyplant metabolitestoxicology

Identifiers

PMID40949153
PMCPMC12423078

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.