Evidence map›Paper›PMID 40949175›Full record

ArticleBiomaterials and biosystems2025

Evaluating the potential hepatotoxicity from hip implant wear products-An

Shriya Thakur, Hemalatha Kanniyappan, Puranjay Gupta, Govindaraj Perumal, Robert Hillwig, Vedant V Bodke, Salman R Khetani, Mathew T Mathew

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials and biosystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shriya ThakurRegenerative Medicine and Disability Research Lab (RMDR), Department of Biomedical Science, UIC College of Medicine Rockford, Rockford, USA.
Hemalatha KanniyappanDepartment of Chemistry and Biochemistry, Worcester Polytechnic Institute (WPI), MA, USA.
Puranjay GuptaRegenerative Medicine and Disability Research Lab (RMDR), Department of Biomedical Science, UIC College of Medicine Rockford, Rockford, USA.
Govindaraj PerumalRegenerative Medicine and Disability Research Lab (RMDR), Department of Biomedical Science, UIC College of Medicine Rockford, Rockford, USA.
Robert HillwigRegenerative Medicine and Disability Research Lab (RMDR), Department of Biomedical Science, UIC College of Medicine Rockford, Rockford, USA.
Vedant V BodkeDepartment of Biomedical Engineering, UIC Chicago, Chicago, USA.
Salman R KhetaniDepartment of Biomedical Engineering, UIC Chicago, Chicago, USA.
Mathew T MathewRegenerative Medicine and Disability Research Lab (RMDR), Department of Biomedical Science, UIC College of Medicine Rockford, Rockford, USA.

Funding

Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

Total hip replacement (THR) is recognized as an effective treatment for patients suffering from severe arthritis or hip issues, with approximately 2.5 million hip and knee replacements recorded annually (AJJR, 2021). A significant clinical concern associated with THR is the toxicity caused by metal particles and ions released from the implant surfaces, which can damage local tissue and potentially spread to distant organs, resulting in systemic toxicity. The toxicity, influenced by the size and concentration of the particles and ions, is especially critical in the liver, the body's main metabolic organ and a primary site for implant accumulation. In this study, we aim to investigate the hepatotoxicity of increasing concentrations of cobalt-chromium-molybdenum (CoCrMo) and titanium (Ti) particles/ions (generally called wear products) in remote organs, particularly the liver. We found that these particles and ions enter cells through metal ion transporters and phagocytosis, leading to significant cellular damage, with titanium ions exhibiting the highest toxicity levels, followed by cobalt ions and CoCrMo particles. Our combined

Indexed as

Hip implantsIn-vitro modelsIn-vivo modelsLiver cellsSystemic toxicityTHR

Identifiers

PMID40949175
PMCPMC12423597

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.