Evidence map›Paper›PMID 40949263›Full record

ArticleACS omega2025

Inhibitory Effects and the Potential Mechanism of Phloretin on Animal Fatty Acid Synthase.

Tongchun Lan, Xinru Zhang, Jiarui Xie, Xu Xing, Chunyan Wang, Xiaofeng Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tongchun LanCollege of Life Sciences, University of Chinese Academy of Sciences, No. 19A, Yuquan Road, Beijing 100049, China.
Xinru ZhangCollege of Life Sciences, University of Chinese Academy of Sciences, No. 19A, Yuquan Road, Beijing 100049, China.
Jiarui XieCollege of Life Sciences, University of Chinese Academy of Sciences, No. 19A, Yuquan Road, Beijing 100049, China.
Xu XingCollege of Life Sciences, University of Chinese Academy of Sciences, No. 19A, Yuquan Road, Beijing 100049, China.
Chunyan WangCollege of Life Sciences, University of Chinese Academy of Sciences, No. 19A, Yuquan Road, Beijing 100049, China.
Xiaofeng MaCollege of Life Sciences, University of Chinese Academy of Sciences, No. 19A, Yuquan Road, Beijing 100049, China.ORCID https://orcid.org/0000-0001-9834-5477

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fatty acid synthase (FASN), a critical enzyme involved in lipid biosynthesis, is highly expressed in adipocytes and exhibits aberrant activity in diverse human cancers. Phloretin, a natural dihydrochalcone abundant in apple peels, crabapples, strawberries, and pears, has emerged as a potential modulator of FASN activity. This study investigates phloretin's inhibitory effects on FASN and the underlying mechanisms. Biochemical assays revealed that phloretin inhibited FASN in a dose-dependent manner, with a half-maximal inhibitory concentration (IC

Identifiers

PMID40949263
PMCPMC12423902

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.