Evidence map›Paper›PMID 40949277›Full record

ArticleACS omega2025

Compressive Force Activation of the Neuronal Nitric Oxide Synthase Enzyme.

Lalita Shahu, Yadav Prasad Gyawali, Ting Jiang, Dedunu S Senarathne, Changjian Feng, H Peter Lu

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lalita ShahuCenter for Photochemical Sciences, Department of Chemistry, Bowling Green State University, Bowling Green, Ohio 43403, United States.
Yadav Prasad GyawaliDepartment of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, United States.
Ting JiangDepartment of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, United States.
Dedunu S SenarathneCenter for Photochemical Sciences, Department of Chemistry, Bowling Green State University, Bowling Green, Ohio 43403, United States.ORCID https://orcid.org/0009-0002-6517-3589
Changjian FengDepartment of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, United States.ORCID https://orcid.org/0000-0003-4542-6497
H Peter LuCenter for Photochemical Sciences, Department of Chemistry, Bowling Green State University, Bowling Green, Ohio 43403, United States.ORCID https://orcid.org/0000-0003-2027-428X

Funding

University of New Mexico Center for Metals in Biology and Medicine - equipment supplementP20GM130422 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Sebastian Medina · 2020 to 2026
$20.4M
Pilot Project CoreP30ES032755 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI FENG, CHANGJIAN (JIM) · 2022 to 2025
$5.2M
Defining Functional Dynamics of Multidomain Redox EnzymesR35GM156443 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Changjian (Jim) Feng · 2025 to 2026
$839k
NIEHS NIH HHS P30 ES032755NIGMS NIH HHS P20 GM130422NIGMS NIH HHS R35 GM156443
6 · The paper itself

Abstract

Calmodulin (CaM), a calcium-sensing protein, regulates the production of nitric oxide (NO) by the nitric oxide synthase (NOS) enzyme. It is interesting to decipher the control mechanism of CaM-dependent NO biosynthesis by the NOS isoforms, as NO is a ubiquitous intercellular signaling molecule in numerous physiological processes. It is generally accepted that 4Ca

Identifiers

PMID40949277
PMCPMC12423791

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.