ArticleTranslational andrology and urology2025
Assessments of neurogenic bladder dysfunction induced by spinal cord injury, bladder outlet obstruction and diabetes: a comparative study of rat models.
Article in Translational andrology and urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Induced diabetic neurogenic bladder animal models: application characteristics and standardization proposals via systematic data mining.Frontiers in endocrinology · 2026Pooled it
- Stem Cell-Based Strategies for Fibrotic and Neurogenic Bladder Disorders: Current Evidence, Translational Challenges, and Future Directions.Current issues in molecular biology · 2026Review
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14 authors.
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Abstract
Background: Neurogenic bladder (NB) refers to urinary storage and voiding dysfunction resulting from neurological disorders. Animal models of NB are commonly used in preclinical studies, but the distinct characteristics of various modeling techniques are infrequently compared. This study aimed to evaluate and compare the functional and pathological outcomes of different NB rat models. Methods: Three rat NB models were induced by spinal cord injury (SCI), bladder outlet obstruction (BOO), and diabetes. Blood urea nitrogen (BUN) and serum creatinine (Scr) levels, along with urine flow dynamics, were assessed at weeks 1, 2, 4, and 8. At the 10-week endpoint, animals were euthanized, and bladder weights were recorded for each specimen. Pathological analysis and western blotting were conducted to evaluate bladder muscle fibrosis. Results: All three rat NB models were successfully established. At week 8, the average maximum/minimum bladder pressures for the SCI, BOO, and diabetic NB rats were 34.0/27.8, 40.4/30.2, and 32.1/28.8 mmH Conclusions: The three NB rat models effectively replicated clinical and pathological features, including reduced bladder compliance, renal dysfunction, and bladder fibrosis. Among these models, SCI offers the fastest method for inducing NB. Renal function impairment was more pronounced in the SCI- and BOO-induced NB models, with BOO resulting in the most significant pathological changes in the bladder.
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