ArticleFrontiers in human neuroscience2025
Deep medullary vein dysfunction is associated with cerebral microbleeds in cerebral small vessel disease.
Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study investigated the association between deep medullary vein (DMV) dysfunction and the development of cerebral microbleeds (CMB) in patients with cerebral small vessel disease (CSVD), with a particular focus on the contribution of extracellular fluid accumulation. Methods: This was a cross sectional study. Clinical and imaging data from 176 patients with CSVD were consecutively collected between July 2024 and May 2025. DMV visibility was scored on a scale of 0-18 using susceptibility-weighted imaging (SWI). CMB were quantified on SWI magnitude images and categorized into three groups: absent CMB, mild CMB (1-2 lesions), and extensive CMB (≥3 lesions). Extracellular fluid volume was estimated using free water (FW) values derived from diffusion tensor imaging. Associations between DMV scores, FW values, and CMB burden were evaluated. Results: DMV scores were moderate positively correlated with both CMB burden and FW values ( Conclusion: DMV dysfunction is positively associated with CMB burden in CSVD, partially mediated by increased extracellular fluid accumulation. These findings suggest that impaired venous drainage and interstitial fluid retention may play a role in the pathogenesis of CMB.
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