Evidence map›Paper›PMID 40950074›Full record

ArticlebioRxiv : the preprint server for biology2025

Alternative pre-mRNA Splicing and Gene Expression Patterns in Midbrain Lineage Cells Carrying Familial Parkinson's Disease Mutations.

Yeon J Lee, Khaja Syed, Oriol Busquets, Hanqin Li, Jesse Dunnack, Helen S Bateup, Frank Soldner, Dirk Hockemeyer, Donald C Rio

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yeon J LeeUniversity of California, Berkeley, Molecular and Cell Biology, Berkeley, CA, 94720.ORCID 0000-0003-3756-4515
Khaja SyedUniversity of California, Berkeley, Molecular and Cell Biology, Berkeley, CA, 94720.ORCID 0000-0002-7682-7608
Oriol BusquetsDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Rose F. Kennedy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461.ORCID 0000-0002-1372-9699
Hanqin LiUniversity of California, Berkeley, Molecular and Cell Biology, Berkeley, CA, 94720.ORCID 0000-0001-7995-1084
Jesse DunnackUniversity of California, Berkeley, Molecular and Cell Biology, Berkeley, CA, 94720.ORCID 0000-0002-0387-0090
Helen S BateupUniversity of California, Berkeley, Molecular and Cell Biology, Berkeley, CA, 94720.ORCID 0000-0002-0135-0972
Frank SoldnerDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Rose F. Kennedy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461.ORCID 0000-0002-7102-8655
Dirk HockemeyerUniversity of California, Berkeley, Molecular and Cell Biology, Berkeley, CA, 94720.ORCID 0000-0002-5598-5092
Donald C RioUniversity of California, Berkeley, Molecular and Cell Biology, Berkeley, CA, 94720.ORCID 0000-0002-4775-3515

Funding

DNA transposons and alternative pre-mRNA splicing.R35GM118121 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI RIO, DONALD C · 2016 to 2025
$6.7M
Genome Sequencer FLXS10RR029668 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI NGAI, JOHN J. · 2010 to 2010
$623k
Illumina Sequencer to Facilitate Functional Genomics at BerkeleyS10RR027303 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI TAYLOR, JOHN W. · 2010 to 2010
$500k
LTQ XL Linear Quadrupole Ion Trap Mass SpectrometerS10RR025622 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI KOHLSTAEDT, LORI · 2009 to 2009
$463k
NCRR NIH HHS S10 RR025622NCRR NIH HHS S10 RR027303NCRR NIH HHS S10 RR029668NIGMS NIH HHS R35 GM118121
6 · The paper itself

Abstract

Parkinson's disease (PD) arises from genetic and environmental factors. Human genetics has identified mutations in ~20 inherited familial genes linked to monogenic forms of PD. To investigate the effects of individual familial PD mutations, human pluripotent embryonic stem cells (hPSCs) carrying 12 distinct familial PD mutations were differentiated into midbrain lineage cells, including dopaminergic (mDA) neurons. Global gene expression and pre-mRNA splicing patterns were analyzed in midbrain cultures carrying pathogenic PD mutations in the

Identifiers

PMID40950074
PMCPMC12424998

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.