Evidence map›Paper›PMID 40950088›Full record

ArticlebioRxiv : the preprint server for biology2025

BMP9 regulates the endothelial secretome to drive pulmonary hypertension.

Ying Zhong, Peiran Yang, Luca Troncone, Oleg V Kovalenko, Eva M Fast, Shreyas Rajesh, Sydney Lavoie, Kathleen E Tumelty, Elizabeth Shin, Taylor A Covington and 18 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Ying ZhongCardiovascular Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Peiran YangCardiovascular Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Luca TronconeCardiovascular Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Oleg V KovalenkoPfizer BioMedicine Design, Cambridge, MA, USA.
Eva M FastPfizer Inflammation and Immunology, Cambridge, MA, USA.
Shreyas RajeshCardiovascular Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Sydney LavoiePfizer Inflammation and Immunology, Cambridge, MA, USA.
Kathleen E TumeltyPfizer Centers for Therapeutic Innovation, Cambridge, MA, USA.
Elizabeth ShinCardiovascular Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Taylor A CovingtonCardiovascular Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Ana ZeghibeCardiovascular Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Marc H WadsworthPfizer Inflammation and Immunology, Cambridge, MA, USA.
Stephen M ChristensenPfizer Inflammation and Immunology, Cambridge, MA, USA.
Robin NathansPfizer Centers for Therapeutic Innovation, Cambridge, MA, USA.
Susan A BenardPfizer BioMedicine Design, Cambridge, MA, USA.
Xianchun TangPfizer BioMedicine Design, Cambridge, MA, USA.
Shakey A QuaziPfizer Pharmacokinetics Dynamics and Metabolism, Cambridge, MA, USA.
Lillian R WorstCardiovascular Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Megan E McNeilCardiovascular Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Stephanie S KimCardiovascular Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Geoffrey D BocoboCardiovascular Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Robert SzulcekLaboratory of in vitro modeling systems of pulmonary and thrombotic diseases, Institute of Physiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Harm J BogaardPulmonary Medicine Division, Amsterdam University Medical Center, Amsterdam, Netherlands.
Kevin M HartPfizer Inflammation and Immunology, Cambridge, MA, USA.
Erik M Martinez-HackertDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, USA.
Stephen P BerasiPfizer Centers for Therapeutic Innovation, Cambridge, MA, USA.
Christine HuardPfizer Centers for Therapeutic Innovation, Cambridge, MA, USA.
Paul B YuCardiovascular Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2145-4944

Funding

Novel probes of BMP and TGF-beta signaling and functionR01AR057374 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI YU, PAUL B · 2010 to 2023
$4.5M
Context-specific angiogenic signaling in the pulmonary vasculatureR01HL159443 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI YU, PAUL B · 2021 to 2024
$2.4M
Molecular imaging of angiogenic activity in pulmonary arterial hypertensionR01HL131910 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI YU, PAUL B · 2016 to 2018
$2.3M
NHLBI NIH HHS R01 HL131910NHLBI NIH HHS R01 HL159443NIAMS NIH HHS R01 AR057374
6 · The paper itself

Abstract

BMP9, a pleiotropic growth factor cytokine that regulates endothelial function, is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). Loss-of-function mutations in

Indexed as

bone morphogenetic protein (BMP)growth and differentiation factor (GDF)pulmonary arterial hypertension (PAH)vascular biology

Identifiers

PMID40950088
PMCPMC12424817

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.