Evidence map›Paper›PMID 40950116›Full record

ArticlebioRxiv : the preprint server for biology2025

Identification of bacterial signals that modulate enteric sensory neurons to influence behavior in

Cassi Estrem, Malvika Dua, Colby P Fees, Greg J Hoeprich, Matthew Au, Bruce L Goode, Lingyi L Deng, Steven W Flavell

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Cassi EstremHoward Hughes Medical Institute, Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Malvika DuaHoward Hughes Medical Institute, Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Colby P FeesDepartment of Biology, Brandeis University, Waltham, MA, USA.
Greg J HoeprichDepartment of Biology, Brandeis University, Waltham, MA, USA.
Matthew AuAnalytical Instrumentation Core, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Bruce L GoodeDepartment of Biology, Brandeis University, Waltham, MA, USA.
Lingyi L DengAnalytical Instrumentation Core, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Steven W FlavellHoward Hughes Medical Institute, Picower Institute for Learning & Memory, Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Neural Mechanisms that Underlie Flexible Sensory Control of Behavioral States in C. elegansR01DC020484 · NIDCD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Steven Willem Flavell · 2023 to 2026
$1.5M
Dissecting the functional organization of the serotonergic system in C. elegansR01GM135413 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FLAVELL, STEVEN WILLEM · 2020 to 2023
$1.2M
New molecular pathways that link gut microbiota to neural circuit activity and behaviorF32NS116107 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESTREM, CASSI E · 2020 to 2021
$153k
NIDCD NIH HHS R01 DC020484NIGMS NIH HHS R01 GM135413NIH HHS P40 OD010440NINDS NIH HHS F32 NS116107
6 · The paper itself

Abstract

The bacterial microbiome influences many aspects of animal health and disease. Some bacteria have beneficial functions, for example providing nutrients, whereas others act as pathogens. These bacteria are sensed by host cells to induce adaptive changes in physiology and behavior. While immune and intestinal cells detect bacterial signals through well-characterized mechanisms, recent studies indicate that neurons can also directly sense bacterial signals. However, the bacterial sensory mechanisms in neurons are less well understood. In the nematode

Identifiers

PMID40950116
PMCPMC12425002

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.