ArticlebioRxiv : the preprint server for biology2025
A switch in kappa opioid receptor signaling from inhibitory to excitatory induced by stress in a subset of cortically-projecting dopamine neurons.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The kappa opioid receptor (KOR) has shown potential as a therapeutic target for several neuropsychiatric disorders including major depressive disorder, chronic pain, and substance use disorder. Signaling of G protein coupled receptors (GPCRs) like the KOR is generally thought to change in magnitude, not valence, with behavior states. Here we investigated KOR modulation of ventral tegmental area (VTA) neurons following an acute, behaviorally aversive manipulation. Methods: KOR agonist responses were measured with whole cell recordings in acute brain slices containing the VTA from male and female rats. Slices were made <1 hr, 3 days or 5 days after a foot shock or sham session. Slices from untreated rats were used to determine the mechanism of action. Recordings were also made in neurons labeled by the retrograde tracer DiI to evaluate circuit specificity. Place conditioning to intra-VTA KOR agonist injections was performed in sham vs shock rats. Results: After acute stress KOR activation excited a subset of VTA dopamine neurons. In slices from untreated animals, brief corticotrophin releasing factor (CRF) exposure Conclusions: After acute aversive stress, KOR activation in the VTA excites, rather than inhibits, dmPFC-projecting VTA dopamine neurons. This change can be generated by activating the CRF system and interferes with the aversiveness of VTA KOR activation.
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