Evidence map›Paper›PMID 40950132›Full record

ArticlebioRxiv : the preprint server for biology2025

Mapping early PRC2 nucleation sites upon Suz12 reintroduction reveals features of

Itzel Alejandra Hernández-Romero, Carlos Alberto Peralta-Alvarez, Abraham Román-Figueroa, Nallely Cano-Domínguez, Maribel Soto-Nava, Hongwei Zhou, Xin Huang, Félix Recillas-Targa, Augusto Cesar Poot-Hernandez, Mayra Furlan-Magaril and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Itzel Alejandra Hernández-RomeroDepartamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular (IFC), Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.ORCID 0000-0002-2728-8329
Carlos Alberto Peralta-AlvarezUnidad de Bioinformática y Manejo de la Información. IFC, UNAM. Mexico City 04510, Mexico.ORCID 0000-0001-6103-5133
Abraham Román-FigueroaDepartamento de Genética Molecular, IFC, UNAM. Mexico City 04510, Mexico.ORCID 0000-0002-6306-6803
Nallely Cano-DomínguezDepartamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular (IFC), Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.
Maribel Soto-NavaCentro de Investigación en Enfermedades Infecciosas (CIENI), Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas (INER), Mexico City, Mexico.
Hongwei ZhouDepartment of Medicine, Columbia Center for Human Development and Stem Cell Therapies, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-3537-0875
Xin HuangDepartment of Medicine, Columbia Center for Human Development and Stem Cell Therapies, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.
Félix Recillas-TargaDepartamento de Genética Molecular, IFC, UNAM. Mexico City 04510, Mexico.
Augusto Cesar Poot-HernandezUnidad de Bioinformática y Manejo de la Información. IFC, UNAM. Mexico City 04510, Mexico.
Mayra Furlan-MagarilDepartamento de Genética Molecular, IFC, UNAM. Mexico City 04510, Mexico.
Santiago Avila-RiosCentro de Investigación en Enfermedades Infecciosas (CIENI), Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas (INER), Mexico City, Mexico.
David Valle-GarciaLaboratorio de Epigenómica del Envejecimiento, Centro de Investigación sobre el Envejecimiento, Cinvestav Sede Sur, Mexico City 14330, Mexico.ORCID 0000-0002-3397-3103
Jianlong WangDepartment of Medicine, Columbia Center for Human Development and Stem Cell Therapies, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-1317-6457
Victor Julian ValdesDepartamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular (IFC), Universidad Nacional Autónoma de México (UNAM), Mexico City 04510, Mexico.ORCID 0000-0001-6157-1358

Funding

Therapeutic value and mechanistic action of PSPC1 in AMLR01CA285299 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jianlong Wang, Mingjiang Xu · 2024 to 2026
$3.0M
A Nucleolar Paradigm for Pluripotency of Human Embryonic Stem CellsR01HD114122 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Jianlong Wang · 2024 to 2026
$1.6M
Decoding NSUN2-mediated translational control of pluripotent stem cellsR21HD116446 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WANG, JIANLONG · 2024 to 2025
$452k
NCI NIH HHS R01 CA285299NICHD NIH HHS R01 HD114122NICHD NIH HHS R21 HD116446
6 · The paper itself

Abstract

Polycomb domains safeguard cell identity by maintaining lineage-specific chromatin states enriched in repressive histone modifications, preserving the epigenetic memory of cell lineages. While Polycomb Repressive Complex 2 (PRC2) can re-establish its occupancy after perturbation, the mechanisms that guide

Indexed as

Epigenetic memoryPolycombPRC2 de novo recruitmentSuz12 Degron

Identifiers

PMID40950132
PMCPMC12424729

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.