Evidence map›Paper›PMID 40950164›Full record

ArticlebioRxiv : the preprint server for biology2025

PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition.

Godhev Kumar Manakkat Vijay, Bala Ramaswami, Steven Gierlack, Nicholas A Pease, Peter Gerges, Dianyu Chen, Kairavee Thakkar, Luis Mena Hernandez, Swapnil Keshari, Heping Xu and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Godhev Kumar Manakkat Vijay
Bala Ramaswami
Steven Gierlack
Nicholas A Pease
Peter Gerges
Dianyu Chen
Kairavee Thakkar
Luis Mena Hernandez
Swapnil Keshari
Heping Xu
Nathan Salomonis
Jishnu Das
David M Rothstein

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Germinal-center (GC) B-cell responses are defined by many positive regulators of affinity maturation, but few components that restrain clonal dominance, notably

Identifiers

PMID40950164
PMCPMC12424711

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.