ArticleJournal of gastrointestinal oncology2025
The incidence and risk factors of venous thromboembolism in patients with pancreatic cancer: a systematic review and meta-analysis.
Article in Journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Extravascular coagulation stabilizes pro-fibrotic stromal states via tumor-intrinsic PAR1 signaling in pancreatic ductal adenocarcinoma.bioRxiv : the preprint server for biology · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Venous thromboembolism (VTE) is a common complication of malignant tumors. The incidence of VTE in patients with pancreatic cancer (PC) may be higher than that in other patients, but varies significantly between studies. Therefore, we aimed to investigate the incidence and risk factors for VTE in patients with PC. Methods: We searched relevant studies from seven electronic databases from their inception to December 25, 2024. The incidence of VTE, odds ratio (OR), and 95% confidence interval (CI) were extracted to evaluate the incidence of VTE and its risk factors in PC patients. The robustness of the results was tested by sensitivity analysis. We used funnel plot and Egger test to assess publication bias. Results: A total of 61 articles were included in this study, including 29,921 patients. The incidence of VTE was 15.6%. Tumor location (OR =1.92; 95% CI: 1.25-2.94), poorly differentiated (OR =2.54; 95% CI: 1.53-4.23), tumor, node, metastasis (TNM) stage IV (OR =2.82; 95% CI: 1.12-7.08), metastasis (OR =2.16; 95% CI: 1.59-2.93) and higher D-dimer (OR =4.33; 95% CI: 1.26-14.86) were risk factors for VTE. Conclusions: The incidence of VTE is high in patients with PC. The tumor located in the body or tail, poorly differentiated, stage IV cancer, distant metastasis, and increased D-dimer levels after surgery are risk factors for VTE. The limitations mainly include high heterogeneity. This indicates that such high-risk patients should be identified early in clinical work, and attention should be paid to the evaluation and intervention for VTE in patients with PC.
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