Evidence map›Paper›PMID 40950496›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Effects on hippocampal activity following 5-HT4 receptor agonism in unmedicated patients with depression: the RESTAND study.

Angharad N de Cates, Amy L Gillespie, Jessica Scaife, Marieke A G Martens, James Carson, Beata Godlewska, Wendy Howard, Anutra Guru, Philip J Cowen, Catherine J Harmer and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Angharad N de CatesInstitute for Mental Health, University of Birmingham, Edgbaston, Birmingham, UK.
Amy L GillespieUniversity Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Jessica ScaifeUniversity Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Marieke A G MartensUniversity Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
James CarsonUniversity Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Beata GodlewskaUniversity Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Wendy HowardUniversity Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Anutra GuruUniversity Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Philip J CowenUniversity Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Catherine J HarmerUniversity Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Susannah E MurphyUniversity Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Cognitive impairment is a common but under-treated feature of Major Depressive Disorder (MDD). Preclinical and early human studies suggest that 5-HT

Identifiers

PMID40950496
PMCPMC12425025

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.