Evidence map›Paper›PMID 40950548›Full record

ArticlePain reports2025

Mitogen- and stress-activated kinase 1 in primary sensory neurons contributes to formalin-induced tonic pain.

Jahanzaib Irfan, Rizki M Febrianto, Paolo La Montanara, Michelle Y Meng, Thomas H Hutson, David Zimmermann, Krisztina Deak-Pocsai, Deemah Aldossary, Jianglin Wang, Simone Di Giovanni and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jahanzaib IrfanNociception Group, APMIC, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, United Kingdom.
Rizki M FebriantoNociception Group, APMIC, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, United Kingdom.
Paolo La MontanaraNociception Group, APMIC, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, United Kingdom.
Michelle Y MengNociception Group, APMIC, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, United Kingdom.
Thomas H HutsonDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, United Kingdom.
David ZimmermannAustria Division of Neuroscience, Department of Physiology and Biomedical Physics, Institute of Physiology, Medical University of Innsbruck, Innsbruck, Austria.
Krisztina Deak-PocsaiDepartment of Physiology, University of Debrecen, Debrecen, Hungary.
Deemah AldossaryNociception Group, APMIC, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, United Kingdom.
Jianglin WangNociception Group, APMIC, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, United Kingdom.
Simone Di GiovanniDepartment of Brain Sciences, Imperial College London, Hammersmith Hospital, London, United Kingdom.
Michaela KressAustria Division of Neuroscience, Department of Physiology and Biomedical Physics, Institute of Physiology, Medical University of Innsbruck, Innsbruck, Austria.
Istvan NagyNociception Group, APMIC, Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The nuclear mitogen- and stress-activated kinases (MSKs) play a critical role in the development and persistence of pain after tissue injury. Objectives: Here, we ascertained the MSK isoform, the cells and mechanisms, which mediate MSKs' pronociceptive function. Methods: Nocifensive behaviour evoked by subcutaneous formalin injection into the paw was quantified in wild type (WT), MSK1 and MSK2 global knock out (MSK1 Results: MSK1 Conclusion: MSK1 constitutes the principal MSK isoform, which is critically important for regulating cellular components that enable the transient activation of a specific subpopulation of nociceptors by formalin.

Indexed as

Calcitonin gene–related peptideDorsal root ganglionFormalin testMSK1Nociceptors

Identifiers

PMID40950548
PMCPMC12425037

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.