ArticleTranslational cancer research2025
Thyroid differentiation score-related genes and prognostic model for thyroid cancer.
Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Tumor microenvironment-guided targeted and immunotherapy in anaplastic thyroid cancer: a literature review from preclinical models to clinical translation.Translational cancer research · 2026Review
- Regulation ofBiology · 2025Article
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Authors and funding
4 authors.
Funding
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Abstract
Background: Thyroid differentiation score (TDS) reflects the differentiation degree of thyroid cancer (THCA). This study aimed to construct a TDS-related prognostic risk model for THCA and explore the potential biomarkers. Methods: Using The Cancer Genome Atlas (TCGA)-THCA dataset, overlapping differentially expressed genes (DEGs) between THCA-DEGs and TDS-DEGs were identified for functional enrichment analyses to determine their biological functions. Least absolute shrinkage and selection operator (Lasso) and Cox regression analyses were applied to construct a prognostic model. The model's predictive performance was validated through Kaplan-Meier curves, receiver operating characteristic curves, and decision curve analyses. Gene set enrichment analysis (GSEA) was performed to explore the functional pathways. Single-cell RNA sequencing analysis was performed to further explore the role of risk genes. Results: A four-gene risk model, including ATPase secretory pathway Ca Conclusions: The TDS-related gene risk model demonstrates strong prognostic utility in THCA. UST may inhibit the p53 signaling pathway to activate CD4
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