Evidence map›Paper›PMID 40950693›Full record

ArticleTranslational cancer research2025

Prognostic implication of endoplasmic reticulum stress-related gene signature in lung adenocarcinoma and its effect on tumor immunity.

Yangyang Xu, Tingting Cai, Jun Xie, Qian He, Chong Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Yangyang Xu *Department of Respiration, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Tingting Cai *Department of Respiration, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Jun XieDepartment of Respiration, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Qian HeDepartment of Respiration, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Chong LiDepartment of Respiration, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Endoplasmic reticulum stress (ERS) can affect the efficacy of anti-tumor therapy (chemotherapy, targeted therapy and immunotherapy) by regulating tumor immune microenvironment. This study aims to develop a prognostic prediction model based on the expression profiles of ERS-related genes to guide the treatment of lung adenocarcinoma (LUAD). Methods: The 16-gene prognostic signature was established to predict the prognosis of LUAD patients using The Cancer Genome Atlas (TCGA) database. We applied consensus clustering and found that LUAD could be divided into two groups based on the expression of Results: We successfully constructed a 16-gene prognostic signature and a nomogram to help individualize outcome prediction in LUAD. The ERS risk signature is an independent prognostic factor for LUAD patients, and a higher score indicates a poorer prognosis. Through consensus clustering based on the expression of Conclusions: The ERS-associated gene signature can effectively predict the prognosis of LUAD patients. In addition, we found that

Indexed as

Endoplasmic reticulum stress (ERS)immune infiltrationlung adenocarcinoma (LUAD)prognosis

Identifiers

PMID40950693
PMCPMC12432767

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.