ArticleFrontiers in psychiatry2025
Nonlinear association between TyG-related Indices and motoric cognitive risk syndrome in depressive individuals: evidence from the CHARLS study.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Triglyceride-Glucose-Waist-to-Weight Index: Novel Biomarker for Mild Cognitive Impairment in Older People With Sarcopenic Obesity.Journal of cachexia, sarcopenia and muscle · 2026Article
- TyG index and mild cognitive impairment and dementia: a review of current evidence.Frontiers in aging neuroscience · 2026Review
- Association of weight-adjusted waist index with motoric cognitive risk syndrome in Chinese adults Aged ≥ 60 years.Lipids in health and disease · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Motoric Cognitive Risk Syndrome (MCR), defined by cognitive complaints and slow gait, is a pre-dementia condition linked to metabolic dysfunction. The triglyceride-glucose (TyG) index and its composite derivatives are surrogate markers of insulin resistance and may contribute to cognitive decline. This study investigated the associations between TyG-related indices and MCR risk in middle-aged and older adults with depressive symptoms, focusing on nonlinear relationships and subgroup modifications. Methods: This study included 5,657 participants aged ≥45 years from the China Health and Retirement Longitudinal Study (CHARLS). Associations between four TyG-related indices (TyG, TyG-BMI, TyG-WC, TyG-WHtR) and MCR were assessed using logistic regression. Nonlinear associations were examined via generalized additive models and two-piecewise linear regression. Stratified analyses explored effect modifications by age, sex, education, and depressive status. Results: All TyG-related indices were positively associated with MCR. TyG-BMI demonstrated the strongest and most consistent association, with a significant threshold at 276.05. Below this point, MCR risk increased with TyG-BMI (OR = 1.01; 95% CI: 1.004-1.017; P = 0.003), while no association was found above it (P = 0.416). Similar nonlinear trends were observed in depressive individuals. Subgroup analyses indicated stronger associations in older adults (≥60 years). Conclusion: TyG-BMI demonstrates a nonlinear association with MCR risk and may serve as an accessible biomarker for early cognitive risk detection in depressive individuals.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.