ArticleNoro psikiyatri arsivi2025
NLRP2 Immunoreactivity in Mouse Brain After Cortical Spreading Depolarization.
Article in Noro psikiyatri arsivi, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The link between spreading depolarization and innate immunity in the central nervous system.The journal of headache and pain · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The objective of this study is to elucidate the expression pattern and alterations of NLRP2 following a single cortical spreading depolarization (CSD). Method: Brain tissue was obtained by cardiac perfusion at the 15th minute after CSD in optogenetically inducible Thy1-ChR2-YFP (n=3) mice. NLRP2 expression was examined in the obtained brain tissue sections by immunofluorescence staining and compared with NLRP2 expression pattern in the sections obtained from the control group (n=3) and naive mice (n=1). The cellular source of NLRP2 is demonstrated by dual staining with NeuN and S100β. Results: Cellular immunoreactivity of NLRP2 was evident in the cortical and subcortical regions of sham and naive group brains. This immunoreactivity exhibited a notable reduction in CSD-induced brains. The the majority of cells expressing NLRP2 exhibited colocalization with NeuN, a neuronal marker, while a smaller subset demonstrated merging with S100β, an astrocyte marker. Conclusion: This study revealed the decreased immunoreactivity of NLRP2 after single CSD in early period.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.