ArticleHealth science reports2025
Relationship of the TG/HDL Ratio With Cognition Function in Older Adults (≥ 60 Years): A Cross-Sectional Analysis of NHANES 2011-2014.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Methodological Considerations in TG/HDL Ratio and Cognitive Function in Older Adults.Health science reports · 2025Article
- Relationship of the TG/HDL Ratio With Cognition Function in Older Adults (≥ 60 Years): A Cross-Sectional Analysis of NHANES 2011-2014.Health science reports · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aim: The relationship between the TG/HDL-C ratio and cognitive impairment in the general US elderly population aged 60 years and older is not well understood. This study aimed to investigate the association between TG/HDL-C ratio and cognitive function in older adults in the US. Methods: In this cross-sectional study (NHANES 2011-2014), 1340 participants underwent cognitive assessments: CERAD (memory), Animal Fluency (verbal fluency), and DSST (processing speed). Global cognition was derived from standardized Z-scores. Survey-weighted multivariate linear regression evaluated associations between TG/HDL-C (continuous/quartiles) and cognitive scores, adjusted for demographics, lifestyle, and comorbidities. Nonlinearity was tested via restricted cubic splines. Results: Higher TG/HDL-C correlated with poorer cognitive performance. Compared to Q1 (lowest), Q4 (highest) had significantly lower DSST ( Conclusion: Elevated TG/HDL-C is independently associated with worse cognitive function in older US adults, particularly impacting processing speed and executive function. These findings underscore lipid dysregulation's role in cognitive aging, supporting targeted interventions for metabolic health.
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Registered trials
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