ArticleCureus2025
Platypnea-Orthodeoxia Syndrome From Atrial Septal Defects: A Rare Primum Case and Literature Review.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Platypnea-orthodeoxia syndrome (POS) is characterized by hypoxemia that worsens in the upright position and improves when lying down. While various causes exist, most cases involve intracardiac shunting through a patent foramen ovale, whereas atrial septal defects (ASDs) are less common and present in diverse embryological forms. Most documented ASD-associated cases involve the secundum type, whereas the primum subtype remains notably rare in the literature. We report a rare case of POS caused by a primum ASD in a 68-year-old female. Transesophageal echocardiography was essential for locating the primum ASD, which facilitated successful percutaneous closure and complete resolution of her symptoms. Additionally, we reviewed 18 published cases of ASD-associated POS to better characterize the presentation, anatomical contributors, and treatment outcomes of this cause.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.