Evidence map›Paper›PMID 40951196›Full record

ArticleCureus2025

Pregnancy-Induced Atypical Hemolytic Uremic Syndrome.

Alexander Den Boef, Sneh Parekh, Melville C O'Brien, Shiguang Liu, Rafik Jacob

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexander Den BoefDepartment of Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Sneh ParekhDepartment of Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Melville C O'BrienDepartment of Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Shiguang LiuDepartment of Pathology and Laboratory Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Rafik JacobDepartment of Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atypical hemolytic uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy that causes anemia, thrombocytopenia, and acute renal failure. In aHUS, a triggering event can lead to dysregulation of the complement immune system, leading to a cascade of events resulting in clot formation, capillary thrombosis, and renal dysfunction. Numerous triggers for aHUS exist, and pregnancy-associated aHUS (P-aHUS), in particular, is associated with poor maternal outcomes, with high risk for adverse events due to the inherent difficulties in establishing the diagnosis and treatment, along with the sequelae associated with the disease itself. We present a case of P-aHUS here, highlighting the diagnostic challenges, clinical management, and the importance of timely intervention, while also emphasizing the role of the monoclonal antibody drug eculizumab in its treatment.

Indexed as

anemiaatypical hemolytic-uremic syndrome (ahus)eculizumabhemolytic uremic syndromepregnancypregnancy-associated atypical hemolytic uremic syndromerenal dysfunctionthrombocytopenia

Identifiers

PMID40951196
PMCPMC12433318

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.