Evidence map›Paper›PMID 40952127›Full record

ArticleJournal of neurochemistry2025

Extracellular Vesicles Released From Cortical Neurons Influence Spontaneous Activity of Recipient Neurons.

Franco Luis Lombino, Mohsin Shafiq, Andreu Matamoros-Angles, Jürgen R Schwarz, Kira V Gromova, Daniele Stajano, Bente Siebels, Leonie Bergmann, Tim Magnus, Michaela Schweizer and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Franco Luis LombinoInstitute for Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Mohsin ShafiqInstitute for Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Andreu Matamoros-AnglesInstitute for Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jürgen R SchwarzInstitute for Molecular Neurogenetics, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Kira V GromovaInstitute for Molecular Neurogenetics, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Daniele StajanoInstitute for Molecular Neurogenetics, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Bente SiebelsSection Mass Spectrometry and Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Leonie BergmannDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Tim MagnusDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Michaela SchweizerCore Facility of Morphology and Electron Microscopy, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Franz Lennard RicklefsDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hartmut SchlüterSection Mass Spectrometry and Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Andrew F HillInstitute for Health and Sport, Victoria University, Melbourne, Australia.
Matthias KneusselInstitute for Molecular Neurogenetics, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Markus GlatzelInstitute for Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0002-7720-8817

Funding

Deutsche Forschungsgemeinschaft GL 589/9-1Forschungsförderungsfonds der Medizinischen Fakultät, University Medical Center Hamburg-Eppendorf, Hamburg, Germany NWF-20/10Hamburg Landesforschungsförderung LFF-FV74Horizon 2020 Research and Innovation Program/Marie Sklodowska-Curie 101030402Joachim Herz StiftungPIER Hamburg/Boston Seed grant PHM-2019-03PIER Seed grant PIF 2020-10
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are membranous structures that cells release into the extracellular space. EVs carry various molecules such as proteins, lipids, and nucleic acids, and serve as specialized transporters to influence other cells. In the central nervous system, EVs have been linked to many important processes, including intercellular communication, but molecular details of their physiological functions are not fully understood. Our study aimed to investigate how EVs are released by neuronal cells, and how they affect the neuronal activity of other recipient neurons. We show that mature primary cortical neurons release EVs from both their soma and dendrites. EVs released from neurons closely resemble non-neuronal EVs regarding size and marker proteins, and proteomic analyses showed that neuronally released EVs contain proteins typically acting in pre- and post-synaptic compartments. Interestingly, our analysis revealed that EVs alter spontaneous activity in target neurons by increasing the amplitude of postsynaptic potentials. In summary, our findings elaborate on the role of EVs in synaptic activity modulation in neurons mediated by glutamate receptors.

Indexed as

Cerebral CortexExtracellular VesiclesNeuronsAnimalsCell CommunicationCells, CulturedMiceRatscortexextracellular vesicleshippocampusNMDA receptorsynaptic activity

Identifiers

PMID40952127
PMCPMC12435116

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.