Evidence map›Paper›PMID 40952251›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Virulence-Selective Trap-Capture-Kill Antibacterial Nanostructures With Immune-Metabolic Regulation for Treating Implant-Associated Infections.

Xiaodong Hu, Jiaqi Zhong, Yujiong Chen, Botao Liu, Tianyu Du, Weilai Zhu, Minzhe Zheng, Hongze Liang, Jiahua Ni, Zhaoxiang Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaodong HuAffiliated Li Huili Hospital, Ningbo University, Ningbo, 315040, China.
Jiaqi ZhongAffiliated Li Huili Hospital, Ningbo University, Ningbo, 315040, China.
Yujiong ChenAffiliated Li Huili Hospital, Ningbo University, Ningbo, 315040, China.
Botao LiuAffiliated Li Huili Hospital, Ningbo University, Ningbo, 315040, China.
Tianyu DuHealth Science Center, Ningbo University, Ningbo, 315211, China.
Weilai ZhuPeking University First Hospital, Beijing, 100034, China.
Minzhe ZhengAffiliated Li Huili Hospital, Ningbo University, Ningbo, 315040, China.
Hongze LiangKey Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo, 315211, China.
Jiahua NiCollege of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China.
Zhaoxiang PengAffiliated Li Huili Hospital, Ningbo University, Ningbo, 315040, China.ORCID https://orcid.org/0000-0001-6508-4100

Funding

Foundation of Bethune Zhenxin - Clinical disease diagnosis and treatment 2024-YJ-111-002Foundation Project for Medical Science and Technology of Zhejiang 2025KY219National Natural Science Foundation of China 32 201 139Natural Science Foundation of Zhejiang LGF21H060003Natural Science Foundation of Zhejiang LKLZ25H060001Ningbo Natural Science Foundation 2023S030Ningbo Top Medical and Health Research Program 2 022 020 102
6 · The paper itself

Abstract

The treatment of orthopedic implant-associated infections (IAIs) presents significant challenges due to increasing drug resistance. This study reports a virulence-selective trap-capture-kill antibacterial system for effectively treating persistent infections while promoting local bone tissue regeneration by regulating disordered immune and metabolic microenvironments caused by IAIs. Here, this work fabricates a nanostructured antibacterial system (F-14-TNA) based on a TiO

Indexed as

Anti-Bacterial AgentsNanostructuresProsthesis-Related InfectionsAnimalsHumansMiceTitaniumVirulenceAnti-Bacterial AgentsTitaniumtitanium dioxideantibacterialbone metabolismimmune microenvironmentimplant‐associated infectionsTiO2 nanostructure

Identifiers

PMID40952251
PMCPMC12667538

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.