ArticleAsian Pacific journal of cancer prevention : APJCP2025
Prognostic Value of PKM2 Expression in de novo Metastatic Colorectal Cancer Patients.
Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetastatic colorectal cancer (CRC) is considered one of the lethal neoplasms globally. The embryonic M2 isoform of pyruvate kinase (PKM2), a crucial enzyme regulating glycolysis, promotes tumor cell proliferation and metastasis, and is correlated with unfavourable outcomes among several cancers, including CRC.
methodsThis prospective cohort study included 80 de novo metastatic CRC patients at the Medical Oncology Department, South Egypt Cancer Institute (SECI), Assiut University, from June 2022 to June 2024. We analyzed the impact of PKM2 expression, evaluated by immunohistochemistry (IHC), in metastatic CRC patients, and response to first-line oxaliplatin-based chemotherapy regimens and survival outcomes in the form of progression-free survival (PFS) and overall survival (OS).
resultThe median age of the studied cases was 47 ys, 42 (52.5%) were male, and 54 (67.5%) were left-sided. Our results revealed a statistically significant association between high PKM2 IHC expression and lower overall response rate (ORR), P = 0.001. After a median follow-up time of 13 months(ms), this translated into a statistically significant association between the high PKM2 IHC expression group and lower PFS and OS (6ms vs 10ms; P = 0.008), (12ms vs. 17ms; P = 0.008), respectively.
conclusionOur results concluded that PKM2 IHC expression was one of the independent prognostic factors for OS. This supports the consideration of PKM2 as a promising molecular target for therapeutic strategies in CRC management.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.