Evidence map›Paper›PMID 40952628›Full record

ReviewCurrent atherosclerosis reports2025

Tackling the Cardio-Kidney-Metabolic Burden in Cancer.

Tarek Nahle, Viraj Shah, Harikrishnan Hyma Kunhiraman, Omar M Makram, Ola Ahmed, Sandeep Yerraguntla, Gaurav Gopu, Jenny Vy, Shivam Singh, Tanvi Borse and 6 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current atherosclerosis reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tarek NahleDivision of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA. tnahle@augusta.edu.
Viraj ShahDivision of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Harikrishnan Hyma KunhiramanDivision of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Omar M MakramDivision of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Ola AhmedDivision of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Sandeep YerraguntlaDivision of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Gaurav GopuDivision of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Jenny VyDivision of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Shivam SinghDepart of Internal Medicine, Reading Tower, Tower Health, West Reading, PA, USA.
Tanvi BorseDepartment of Internal Medicine, Parkview Health, Fort Wayne, IN, USA.
Kevin KalinskyWinship Cancer Institute at Emory University, Atlanta, GA, USA.
Anita DeswalDepartment of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Diego SadlerCardio Oncology Section, Department of Cardiovascular Medicine, Heart Vascular and Thoracic Institute, Cleveland Clinic Florida, Weston, FL, USA.
Vipul ChitaliaRenal Section, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Neal L WeintraubDivision of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Avirup GuhaDivision of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.

Funding

Role of Intravenous ultrasound (IVUS) in arteriovenous hemodialysis access dysfunctionR01DK141016 · NIDDK · BOSTON MEDICAL CENTER · PI Vipul C Chitalia, Alik Farber · 2024 to 2026
$2.3M
Thrombotic complication of uremia: role of prothrombotic uremic solutesR01HL132325 · NHLBI · BOSTON MEDICAL CENTER · PI CHITALIA, VIPUL C · 2016 to 2019
$1.7M
NHLBI NIH HHS R01 HL132325NIDDK NIH HHS R01 DK141016Strategically Focused Research Network #847740U.S. Department of Defense #HT94252310158
6 · The paper itself

Abstract

purpose of the reviewThis review aims to examine the clinical relevance of cardio-kidney-metabolic syndrome (CKMS) in oncology, highlighting its role as both a preexisting comorbidity and a consequence of cancer treatment. It aims to integrating CKMS staging into personalized cancer care. RECENT

findingsCKMS is a progressive syndrome marked by dysfunction across cardiovascular, renal, and metabolic systems. Cancer therapies-particularly hormonal agents, immune checkpoint inhibitors, and chemotherapeutics-can accelerate or reveal underlying CKMS through inflammatory and metabolic pathways. Early risk stratification based on CKMS stage enables more effective monitoring, referral, and therapeutic strategies. A stage-based, multidisciplinary approach tailored to cancer type and comorbidity burden is essential for optimizing outcomes. With rising multimorbidity among cancer patients, recognizing and addressing CKMS is increasingly critical. Routine CKMS assessment in oncology offers a pathway for earlier intervention and potentially altering its course. A comprehensive, individualized care model based on CKS stage is necessary to mitigate CKMS-related complications and deliver high-quality, integrated cancer care.

Indexed as

Cardio-Renal SyndromeMetabolic SyndromeNeoplasmsAntineoplastic AgentsComorbidityHumansAntineoplastic AgentsCancerCancer therapyCardio-kidney-metabolic syndromeCardio-oncologyMetabolic syndrome

Identifiers

PMID40952628

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.