ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2025
The Relationship Between PSQI Scores and Glucose Metabolic Dysfunction in Patients with Newly Diagnosed T2DM: The Mediating Role of Body Composition.
Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Association between sleep disorders and alterations in glucose metabolism, insulin, and glucagon in patients with type 2 diabetes.Medicine · 2026Observational
- Sleep patterns, physical activity and glycemic control in newly diagnosed type 2 diabetes patients from a joint perspective: a cross-sectional study.Frontiers in endocrinology · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
introductionType 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized primarily by insulin resistance and hyperglycemia, often leading to multiple complications. Sleep disturbances, including insomnia and sleep apnea, are prevalent in patients with T2DM and are associated with poorer glucose metabolism. Despite research examining the relationship between glucose metabolism, body composition, and sleep quality, the underlying mechanisms remain unclear, particularly within patients with T2DM.
methodsThis study involved 269 newly diagnosed patients with T2DM from January to June 2024. Data collected included demographic information, clinical variables, glycemic markers, and body composition analyses. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI), categorizing participants into poor (PSQI-H) and good sleep quality (PSQI-L) groups. Univariate and multivariate regression analyses, along with mediation analysis, were performed using SPSS 26.0 and R software to explore associations between sleep quality, glycemic markers, and body composition.
resultsSignificant correlations were found between PSQI scores and glycemic markers such as HbA1c, HOMA-IR, and postprandial blood glucose levels, showing that poorer glucose control was correlated with worse sleep quality. Mediation analysis suggested that body composition, particularly the trunk-to-limb fat mass ratio, may act as a statistical mediator in the relationship between glucose metabolism and sleep quality.
conclusionsOur findings highlight the complex relationship between glucose metabolism, body composition, and sleep quality in patients with T2DM. Targeting glucose regulation and body composition may be explored in future studies as potential approaches to improve sleep quality in individuals with T2DM.
trial registrationClinical ChiCTR1900022768.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.