ArticleThe Saudi dental journal2024
Comparative assessment of Omega-3 and CoQ10 as adjuncts to periodontal therapy and total antioxidant capacity of saliva in patients with chronic periodontitis: A double-blind, randomized clinical trial.
Article in The Saudi dental journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Do Adjunctive Therapies with Natural Products Improve Periodontal Clinical Parameters After Non-Surgical Treatment? A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2026Pooled it
- Bioregulatory periodontal medicine: could the molecular networks, inflammation and system biology modify the auto-regulatory capacity of the patients?Frontiers in physiology · 2026Pooled it
- Development and in vitro evaluation of a xylitol/erythritol carbomer gel for xerostomia relief.Odontology · 2026Article
- Comparative evaluation of topical and intramuscular coenzyme Q10 application in non-surgical periodontal disease management: A randomized clinical study.Bioinformation · 2026Article
- Molecular cytokine-dependent mechanisms of periodontitis pathogenesis and the potential for pharmacological IL-1 modulation in disease treatment.Frontiers in dental medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The dental community has shown interest in the potential of Omega-3 and coenzyme Q10 for reducing inflammation in the periodontium. These antioxidant agents may enhance the outcomes of non-surgical periodontal treatments. This study aimed to investigate the potential benefits of CoQ10 and Omega-3 supplements in improving periodontal health and the TAC of saliva in individuals with chronic periodontitis. Methods: In a double-blind, randomized clinical trial, 75 individuals were diagnosed with chronic periodontitis. These individuals were randomly allocated into three groups. The periodontal examination involved a total of 300 teeth across the three groups. The periodontal parameters of the two molars adjacent to the mandible were measured using a periodontal probe. All patients underwent scaling and root planing. Groups A and B received CoQ10 and Omega-3 respectively, while Group C served as the control. The TAC of the non-stimulated saliva samples was evaluated to assess any changes before and after 2 months. Statistical techniques were employed to compare the CAL index and PPD between the groups under study. Results: The analysis of the gingival index indicated a notable reduction in inflammation within the Omega-3 group compared to both the CoQ10 and control groups, with a nearly 30% decrease observed. Furthermore, the bleeding on probing index within the Omega-3 group demonstrated significant improvements when contrasted with the CoQ10 and control groups, with this decrease being statistically significant. Additionally, the levels of TAC in the patients' saliva across all three groups exhibited changes when compared to the initial measurements. Conclusion: These findings provide valuable insights into the potential therapeutic effects of Omega-3 and CoQ10 supplementation on periodontal health and the antioxidant capacity of saliva.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.