Evidence map›Paper›PMID 40952940›Full record

ArticleACS infectious diseases2025

Biocompatible Guanidine-Functionalized Compounds with Biofilm and Membrane Disruptive Activity Against MRSA.

Pamella Fukuda de Castilho, Luana Janaína de Campos, Audifás-Salvador Matus-Meza, Huihua Xing, Diana Liz Jimenez Rolão, Fernanda Galvão, Fabiana Gomes da Silva Dantas, Rongguo Ren, Cameron Dobrotka, Fábio Aguiar-Alves and 2 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pamella Fukuda de CastilhoFaculty of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul 79804-970, Brazil.ORCID 0000-0002-5723-0507
Luana Janaína de CamposDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Audifás-Salvador Matus-MezaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Huihua XingDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Diana Liz Jimenez RolãoFaculty of Health Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul 79804-970, Brazil.
Fernanda GalvãoFaculty of Biological and Environmental Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul 79804-970, Brazil.
Fabiana Gomes da Silva DantasFaculty of Biological and Environmental Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul 79804-970, Brazil.
Rongguo RenCollege of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198-6125, United States.
Cameron DobrotkaDepartment of Pharmaceutical Sciences, Lloyd L. Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, Florida 33401, United States.ORCID 0000-0001-8280-3752
Fábio Aguiar-AlvesDepartment of Pharmaceutical Sciences, Lloyd L. Gregory School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, Florida 33401, United States.
Martin Conda-SheridanDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Kelly Mari Pires de OliveiraFaculty of Biological and Environmental Sciences, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul 79804-970, Brazil.ORCID 0000-0002-9897-7770

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three guanidine-functionalized 3,4-dihydropyrimidin-2(1

Indexed as

Anti-Bacterial AgentsBiocompatible MaterialsBiofilmsCell MembraneGuanidineMethicillin-Resistant Staphylococcus aureusAnimalsLarvaMicrobial Sensitivity TestsStaphylococcal InfectionsSwineAnti-Bacterial AgentsBiocompatible MaterialsGuanidineantimicrobialCA-MRSAguanidineHA-MRSAresistantStaphyloccocus aureus

Identifiers

PMID40952940
PMCPMC12519469

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.