ArticleLupus science & medicine2025
Cortical changes in women with systemic lupus erythematosus with mild cognitive impairment: a voxel-based morphometry and surface-based morphometry study.
Article in Lupus science & medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to reveal the morphological changes of grey matter (GM) in women systemic lupus erythematosus (wSLE) patients with mild cognitive impairment (MCI) with normal conventional MRI.
methodsThe differences in brain morphological indicators among wSLE with MCI, wSLE without MCI and women healthy control (wHC) group were calculated and compared by voxel-based morphometry and surface-based morphometry. The GM volume (GMV), cortical thickness (CT), indicators of cortical complexity, including fractal dimension (FD), gyration index (GI), sulcus depth, the relationship between brain morphological indicators and clinical features, were analysed.
resultsIn comparison to wSLE patients without MCI (n=36), wSLE with MCI (n=26) demonstrated a significant decrease in FD of the left lateral orbitofrontal gyrus. When compared with the wHC group (n=36), both wSLE patients with MCI and wSLE without MCI group exhibited a reduction in GMV in the medial of right superior frontal gyrus, a thinning of CT in the left paracentral and postcentral gyrus as well as in the right pars triangularis gyrus and superior frontal gyrus. Within the wSLE group, Mini-Mental State Examination scores were positively correlated with GMV in the middle of right superior frontal gyrus and with the FD of the left lateral orbitofrontal gyrus.
conclusionWSLE patients with MCI have brain morphological changes such as reduced GMV, thinning CT, reduced FD and increased GI. Cortical morphological changes may be involved in the pathological process of MCI in wSLE patients.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.