ArticleScientific reports2025
The novel HRD motif kinase SPE-60 is required for sperm development and motility in Caenorhabditis elegans.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The intrinsically disordered protein SPE-56 is required for acrosomal-like exocytosis and fertility in Caenorhabditis elegans.Scientific reports · 2026Article
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Abstract
Sexual reproduction requires sperm development, activation and motility. Many of these post-meiotic processes remain incompletely understood. We identified the gene spe-60, which encodes a tau-tubulin kinase with a conserved catalytic HRD motif. Localisation via immunostaining reveals that SPE-60 is present in sperm and dynamically colocalises with membranous organelles (MOs), that store factors essential for activation and fertility. spe-60 null mutants are sterile due to immotile sperm that undergo normal MO-plasma membrane fusion but fail to extend normal pseudopods essential for motility and fertilisation. Furthermore, mutant sperm exhibit arrested spermatocyte development. The functional loss observed in spe-60 null sperm is phenocopied by sperm carrying a CRISPR/Cas-mediated point mutation within the HRD motif. Genetic epistasis places SPE-60 downstream of the serine/threonine kinase SPE-6 in the canonical sperm activation pathway. Thus, SPE-60 is required for sperm development and motility, but not MO fusion. These findings suggest that the HRD-containing kinase SPE-60 fulfils a dual function as a key evolutionarily conserved factor.
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