ArticleNature ecology & evolution2025
Beneficial reversal of dominance maintains a large-effect resistance polymorphism under fluctuating insecticide selection.
Article in Nature ecology & evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Characterizing the detectable and invisible fractions of genomic loci under balancing selection.Molecular biology and evolution · 2026Article
- Insecticide resistance evolution and assisted gene flow interact to shape the evolution of plasticity.bioRxiv : the preprint server for biology · 2026Article
- Epistasis among clustered lineage-specific amino acid substitutions in the Drosophila Trio protein.PLoS genetics · 2026Article
- Seasonal evolution of Drosophila melanogaster abdominal pigmentation is associated with a multifarious selective landscape.Evolution; international journal of organic evolution · 2026Article
- The geometry of dominance shows broad potential for stable polymorphism under antagonistic pleiotropy.bioRxiv : the preprint server for biology · 2026Article
- A century of theories of balancing selection.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Article
- The genetic architecture and spatiotemporal dynamics of adaptation across human-modified landscapes.The New phytologist · 2026Review
- Ecological stoichiometry and life history theory, not the identity of genomic variants, predict rapid adaptation.bioRxiv : the preprint server for biology · 2025Article
- Beneficial reversal of dominance maintains a large-effect resistance polymorphism under fluctuating insecticide selection.Nature ecology & evolution · 2025Article
- Epistasis among clustered lineage-specific adaptive amino acid substitutions in the Drosophila Trio protein.bioRxiv : the preprint server for biology · 2025Article
- Microbiome evolution plays a secondary role in host rapid adaptation.bioRxiv : the preprint server for biology · 2025Article
- A transposable element insertion in AUX/IAA16 disrupts splicing and causes auxin resistance in Bassia scoparia.The Plant journal : for cell and molecular biology · 2025Article
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Abstract
Large-effect standing genetic variation is commonly found in natural populations and must be maintained in the face of directional natural selection. Theory suggests that under fluctuating selective pressures, beneficial reversal of dominance-where alleles are dominant when beneficial and recessive when deleterious-can strongly stabilize large-effect polymorphisms. However, empirical evidence for this mechanism remains limited because testing requires measurements of selection and dominance in fitness in natural conditions. Here we investigate large-effect fitness polymorphisms at the Ace locus of Drosophila melanogaster that confer insecticide resistance and persist at intermediate frequencies worldwide. By combining laboratory and large-scale field mesocosm experiments with insecticide manipulation and mathematical modelling, we show that the benefits of the resistant Ace alleles are dominant in pesticide-rich environments, while their fitness costs are recessive in pesticide-free environments. We further show that temporally fluctuating insecticide selection generates chromosome-scale genomic perturbations at sites linked to the resistant Ace alleles. Overall, our results suggest that beneficial reversal of dominance under temporally fluctuating selection might plausibly contribute to the maintenance of functional genetic variation and, by stabilizing large frequency fluctuations, impact long-range patterns of genomic variation.
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