ReviewNature reviews. Microbiology2026
Erythrocyte invasion in malaria: from molecular mechanisms to rational vaccines.
Review in Nature reviews. Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The long and winding road: On the endoplasmic reticulum of Plasmodium and implications for pathogenesis.PLoS pathogens · 2026Review
- Endogenous living adjuvants for cancer vaccination: Concepts, mechanisms, and design principles.Materials today. Bio · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasmodium parasites, which cause malaria, invade and remodel our red blood cells, creating niches in which they replicate. If erythrocyte invasion is blocked during the blood stage of infection, malaria can be prevented. Indeed, a vaccine that targets a component of the erythrocyte invasion machinery has recently shown efficacy against malaria. Erythrocyte invasion occurs through a sequence of temporally organized molecular processes, such as bridging of the erythrocyte and parasite membranes during invasion by the Plasmodium falciparum PCRCR complex. Structural investigations of human antibodies that target invasion machinery, induced by vaccination or natural infection, have revealed neutralizing epitopes and uncovered mechanisms by which antibodies can potentiate the activity of other antibodies. Using rational, structure-guided protein design, these insights are being leveraged to develop targeted vaccine components, with the first rationally designed blood-stage malaria vaccine immunogen now entering clinical trials.
Indexed as
Identifiers
40954307What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.