SynthesisFluids and barriers of the CNS2025
Choroid plexus volume in brain disorders: a systematic review.
Synthesis in Fluids and barriers of the CNS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Choroid plexus volume in Alzheimer's disease: A systematic review and meta-analysis.Journal of Alzheimer's disease : JAD · 2026Pooled it
- Imaging Biomarkers of the Glymphatic System in the Developing Brain.Korean journal of radiology · 2026Review
- Exploring the link between body physiology and cognition: the role of the brain and aging.npj aging · 2026Article
- Increased free interstitial fluid in the normal appearing brain in idiopathic normal pressure and post-hemorrhagic hydrocephalus despite unchanged choroid plexus size.Neuroradiology · 2026Article
- Article
- Glymphatic surrogate, choroid plexus remodeling, and exploratory brain network analysis in the post-acute phase of anti-NMDAR encephalitis: multimodal MRI evidence for cognitive associations and differential white matter mediation.Frontiers in immunology · 2026Article
- Reduced BOLD-CSF coupling as a potential functional imaging correlate of semantic fluency decline in MRI-negative temporal lobe epilepsy.Frontiers in aging neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundThe choroid plexus is a highly vascularized structure located in the lateral, third, and fourth ventricles of the brain. Recent studies suggest that volumetric changes in choroid plexus volume are associated with progression in various brain diseases. Segmentation algorithms have significantly improved our ability to study choroid plexus volumetrics in relation to various pathologies. Thus, the specific purpose of this review was to describe to what extent choroid plexus volume estimation provides clinically relevant information in brain diseases.
methodsAn extensive literature search was conducted across Pubmed, Embase and Cochrane databases. A comprehensive, detailed qualitative descriptive analysis, and a thorough risk-of-bias assessment were performed for the included studies.
resultsForty-eight studies were included in this systematic review in the categories of multiple sclerosis, neurodegenerative diseases, psychiatric disorders, healthy populations and a group categorized as "other" for all other brain diseases that did not fit into the other categories.
conclusionFor many of the studies included, the patients had a larger choroid plexus volume compared to healthy controls. Evidence is currently insufficient to determine whether CPV enlargement correlates with clinical severity or functional scores. The most common segmentation technique was the automatic segmentation method, followed by manual correction of the segmented choroid plexus. Thus, this review highlights the growing interest choroid plexus volume, its segmentation, and its potential as a biomarker for numerous brain diseases.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.