Evidence mapPaperPMID 40954539Full record

ArticleThe Journal of international medical research2025

Mendelian randomization and mediation analysis reveal the role of immune cells in the pathways between inflammatory factors and glioblastoma.

Ruilong Xu, Yubo Wang, Xiaoshan Ma, Liang Zhang, Yunqian Li

Abstract read
In one paragraph

Article in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruilong XuNeurosurgical Oncology, The First Bethune Hospital of Jilin University, China.
Yubo WangNeurosurgical Oncology, The First Bethune Hospital of Jilin University, China.
Xiaoshan MaNeurosurgical Oncology, The First Bethune Hospital of Jilin University, China.
Liang ZhangObstetrics and Gynecology, The First Bethune Hospital of Jilin University, China.
Yunqian LiNeurosurgical Oncology, The First Bethune Hospital of Jilin University, China.ORCID 0000-0003-2199-8618

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveInflammatory factors and immune cells play crucial roles in glioblastoma multiforme pathophysiology. However, the relationships between these factors and the underlying mechanisms are not fully understood. This study employed Mendelian randomization to investigate the effects of inflammatory factors and immune cells on glioblastoma multiforme risk, specifically focusing on the mediating role of immune cells.MethodsGenetic data on 91 inflammatory factors (e.g. interleukins, CXCL, and fibroblast growth factor; N = 14,824), 731 immune cell phenotypic traits (e.g. CD39

Indexed as

Brain NeoplasmsGlioblastomaInflammationGenome-Wide Association StudyHumansMendelian Randomization AnalysisPolymorphism, Single Nucleotideglioblastoma multiformeimmune cellsInflammatory factorsmediation analysisMendelian randomization

Identifiers

PMID40954539
PMCPMC12665827

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.