ReviewPeerJ2025
Functional characteristics, intercellular interactions and pathophysiological associations of astrocytes in Parkinson's disease.
Review in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Astrocytes orchestrate neuroprotection and pathogenesis via bidirectional neuronal interactions in Parkinson's disease.Journal of physiology and biochemistry · 2026Review
- Polymeric lysosome-targeting chimeras for extracellular α-synuclein degradation in Parkinson's disease.Acta neuropathologica communications · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, and its incidence rate is increasing at an alarming rate. Astrocytes exhibit a complex array of functions that play a critical role in the pathogenesis and progression of PD. These multifaceted functions substantially influence disease development and exacerbation. Although numerous studies have investigated the role of astrocytes in PD, the interactions between astrocytes and other cellular or molecular factors during the course of neurological deterioration in PD have not been comprehensively characterized. Therefore, this review aims to highlight the roles and functional characteristics of astrocytes in PD. Astrocytes are involved in maintaining the blood-brain barrier, clearing α-synuclein, metabolizing glutamate and fatty acids, and protecting neurons. The interactions among astrocytes, microglia, and oligodendrocytes exert dual effects on PD progression. Additionally, the recently recognized phenomena of ferroptosis and cuproptosis have been associated with astrocytic activity. The interplay and regulatory mechanisms linking these forms of cell death to apoptosis and pyroptosis of immune cells in the brain warrant further investigation. This review is intended for researchers, healthcare professionals, and clinicians involved in the study and treatment of PD and its related complications. To ensure comprehensive and unbiased coverage, a systematic literature search was conducted using major scientific databases such as PubMed, Scopus, and Web of Science. Keywords included "Parkinson's disease", "astrocyte", "brain", "signaling mechanisms", and "α-synuclein". Articles were selected based on their relevance to astrocyte-PD interactions, while studies lacking scientific rigor or relevance were excluded. In summary, this review synthesizes current understanding of astrocytic function and mechanisms in PD and proposes potential therapeutic directions based on these insights.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.