Evidence map›Paper›PMID 40955682›Full record

ArticleNMR in biomedicine2025

MRS-Sim: Open-Source Framework for Simulating In Vivo-Like Magnetic Resonance Spectra.

John LaMaster, Georg Oeltzschner, Yan Li

Abstract read
In one paragraph

Article in NMR in biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A Digital Phantom for MR Spectroscopy Data Simulation.Magnetic resonance in medicine · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

John LaMasterMunich Institute of Biomedical Engineering, Technical University of Munich, Munich, Bavaria, Germany.
Georg OeltzschnerRussel H. Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yan LiDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.

Funding

Multimodality Neuroimaging Evaluation of Cognitive Functioning in Lower Grade AstrocytomaR01CA273028 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORDON, JEREMY WILLIAM, LI, YAN · 2022 to 2025
$3.3M
Quantitative Steady-State and Dynamic Metabolic MRI for Evaluating Patients with GliomaR01CA262630 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang, Albert Chen · 2022 to 2026
$3.3M
Towards a comprehensive neurometabolic profile in patients with mild cognitive impairment.R00AG062230 · NIA · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2021 to 2023
$735k
General Linear Modeling For Magnetic Resonance SpectroscopyR21EB033516 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2022 to 2024
$670k
German Academic Exchange Service 57381412NCI NIH HHS R01 CA262630NCI NIH HHS R01 CA273028NIA NIH HHS R00 AG062230NIBIB NIH HHS R21 EB033516NIH HHS R00 AG062230NIH HHS R01 CA262630NIH HHS R01 CA273028NIH HHS R21 EB033516
6 · The paper itself

Abstract

Realistic, in vivo-like synthetic data is increasingly needed to develop and validate methods in magnetic resonance spectroscopy. MRS-Sim is a powerful, open-source framework for simulating such data while providing known ground truth values. Its modularity enables modeling the complexities of MRS data for various in vivo scenarios. The underlying physical equations include both commonly used spectral components of linear-combination fitting routines and two novel components. The first is a 3D

Indexed as

Computer SimulationAlgorithmsHumansMagnetic Resonance Spectroscopydata simulationin vivoMRSopen‐sourcespectroscopysynthetic data

Identifiers

PMID40955682
PMCPMC12439243

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.