Evidence map›Paper›PMID 40955716›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2026

Transition From Psoriasis to Psoriatic Arthritis is Characterized by Distinct Alterations in Peripheral Blood Tc17, Th17, and CD4

Hanna Graßhoff, Sara Comdühr, Henry Nording, Jacob von Esebeck, Philine Letz, Miriam Prohaczka, Handan Gedik, Henner Zirpel, Elisabeth Spallek, Linh Ha-Wissel and 10 more

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In one paragraph

Article in Arthritis & rheumatology (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Hanna GraßhoffDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0003-1395-3268
Sara ComdührDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.
Henry NordingCardioimmunology Group, Medical Clinic II, University Heart Center Lübeck, Lübeck, Germany.
Jacob von EsebeckCardioimmunology Group, Medical Clinic II, University Heart Center Lübeck, Lübeck, Germany.
Philine LetzDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.
Miriam ProhaczkaDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.
Handan GedikInstitute and Comprehensive Center for Inflammation Medicine, University of Lübeck, Lübeck, Germany.
Henner ZirpelInstitute and Comprehensive Center for Inflammation Medicine, University of Lübeck, Lübeck, Germany.
Elisabeth SpallekInstitute and Comprehensive Center for Inflammation Medicine, University of Lübeck, Lübeck, Germany.
Linh Ha-WisselInstitute and Comprehensive Center for Inflammation Medicine, University of Lübeck, Lübeck, Germany.
El-Baraa AdjailiaDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.
Sabrina ArnoldDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.
Konstantinos FourlakisDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.
Sebastian KlapaDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0002-0012-0163
Ingo EitelGerman Centre for Cardiovascular Research, Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany.
Oliver J MüllerDepartment of Internal Medicine V, University of Kiel, Kiel, Germany.
Jens Y HumrichDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.
Gabriela RiemekastenDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.
Diamant ThaçiInstitute and Comprehensive Center for Inflammation Medicine, University of Lübeck, Lübeck, Germany.
Peter LamprechtDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0001-5929-868X

Funding

Deutsche Forschungsgemeinschaft EXC2167Deutsche Forschungsgemeinschaft LA 1339/6-1Deutscher Psoriasis Bund e.V.
6 · The paper itself

Abstract

objectiveCellular mechanisms driving transition from psoriasis to psoriatic arthritis have remained largely elusive. Thus, we investigated changes within the peripheral blood T cell compartment associated with the transition phase.

methodsIn an observational study, 116 patients were examined and categorized into subgroups including psoriasis with at least one risk factor for transition to psoriatic arthritis, subclinical psoriatic arthritis according to EULAR taskforce recommendations from 2023, and definitive psoriatic arthritis meeting the Classification Criteria for Psoriatic Arthritis. Demographic and clinical characteristics of patient subgroups were analyzed. Deep T cell phenotyping using multicolor flow cytometry and machine-learning techniques were applied.

resultsOverlapping T cell endotypes were found among patients with subclinical psoriatic arthritis exhibiting the most notable divergence from the others. Frequencies of effector memory CD4

conclusionTransition from psoriasis to psoriatic arthritis was associated with distinct alterations of the peripheral blood T cell compartment, with Tc17 cells exhibiting the greatest discriminatory power. These findings provide insight into pathomechanisms driving disease progression during transition from psoriasis to psoriatic arthritis and identify Tc17 cells as the foremost novel potential therapeutic target for the prevention of transition.

Identifiers

PMID40955716
PMCPMC12936891

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.