Evidence map›Paper›PMID 40955776›Full record

ArticleJournal of medical Internet research2025

Prompt Engineering in Clinical Practice: Tutorial for Clinicians.

Jialin Liu, Fang Liu, Changyu Wang, Siru Liu

Abstract read
In one paragraph

Article in Journal of medical Internet research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jialin Liu *Department of Medical Informatics, West China Hospital, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0002-1369-4625
Fang Liu *Department of Nephrology, West China Hospital, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0003-1121-3004
Changyu WangDepartment of Medical Informatics, West China Hospital, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0003-4548-331X
Siru LiuDepartment of Biomedical Informatics, Vanderbilt University Medical Center, 2525 West End Ave, Nashville, TN, 37215, United States, 1 615-936-6867.ORCID http://orcid.org/0000-0002-5003-5354

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unlabelled: Large language models (LLMs), such as OpenAI's GPT series and Google's PaLM, are transforming health care by improving clinical decision-making, enhancing patient communication, and simplifying administrative tasks. However, their performance relies heavily on prompt design, as small changes in wording or structure can greatly impact output quality. This presents challenges for clinicians who are not experts in natural language processing (NLP). This tutorial combines prompt engineering techniques tailored for clinical use, covering methods like zero-shot prompting, one-shot prompting, few-shot prompting, chain-of-thought prompting, self-consistency prompting, generated knowledge prompting, and meta-prompting. We provide actionable guidance on defining objectives, applying core principles, iterative prompt refinement, and integration into interoperable electronic health record (EHR) systems. This framework helps clinicians leverage LLMs to improve decision-making, streamline documentation, and enhance patient communication while maintaining ethical standards and ensuring patient safety.

Indexed as

Natural Language ProcessingElectronic Health RecordsHumansclinical practiceGPThuman-AI collaborationlarge language modelprompt engineering

Identifiers

PMID40955776
PMCPMC12439060

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.