Evidence map›Paper›PMID 40956286›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

A "Mesoporous Oxygen Chamber" Scaffold with Antibacterial and Early Immunomodulatory Effect for Promoting Bone Regeneration.

You Fu, Dan Lin, Zhicen Lu, Jian Wang, Jing Zhao, Zhiyuan Zhang, Bing Fang, Xiao Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

You FuDepartment of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai, 200011, China.
Dan LinShanghai University of Medicine and Health Sciences, Shanghai, 201318, China.
Zhicen LuFujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, 350122, China.
Jian WangDepartment of General Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai, 200011, China.
Jing ZhaoShanghai Dingchang Labor Security Consulting Co., Ltd., Shanghai, 200011, China.
Zhiyuan ZhangDepartment of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai, 200011, China.
Bing FangDepartment of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai, 200011, China.
Xiao YangDepartment of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai, 200011, China.ORCID https://orcid.org/0000-0002-5809-587X

Funding

CAMS Innovation Fund for Medical Sciences 2019-I2M-5-037Fujian Key Laboratory of Oral DiseasesFujian Medical University 2023SZ-ZX03National Natural Science Foundation of China 32201104School and Hospital of StomatologyScience and Technology Commission of Shanghai Municipality 22010502600
6 · The paper itself

Abstract

Regeneration of bone defects are frequently hindered by severe inflammation, immunogenicity after bone repairing material implantation, and microbial infections. Oxygen therapy is reported to downregulate the levels of pro-inflammatory cytokines and proteases, alleviating inflammation and promoting regeneration. Mesoporous bioactive glass (MBG) is marked by its osteoinductivity and mesoporous structure for drug delivery. In this study, an oxygen-loaded and antimicrobial peptide (AP)-functionalized scaffold (MBGAPO) is synthesized and proven with sufficient oxygen-delivery capacity of mesopores, promising antibacterial ability against E.coli and MRSA, multiplex-immunomodulatory effects, and potent osteoinductivity both in vitro and in vivo. In cranial defect models of mouse and rat, MBGAPO created a mild immune microenvironment that accelerated inflammation alleviation and facilitated immune cells transformation toward anti-inflammatory phenotypes in the initial stage of bone regeneration, and exhibited a superior immune modulatory effect than Bio-oss (an FDA-approved bone substitute). In vivo results indicated that oxygen delivery promoted bone regeneration within the scaffold, and AP functionalization facilitated the bridging of surrounding tissue in the defect area. In summary, mesoporosity-based oxygen delivery is first proven as a promising osteoimmunology therapeutic strategy, and its combination with antimicrobial peptides can be extended to more regenerative and disease treatment applications that may arouse broader interests of researchers.

Indexed as

Anti-Bacterial AgentsBone RegenerationOxygenTissue ScaffoldsAnimalsAntimicrobial PeptidesMaleMicePorosityRatsRats, Sprague-DawleyTissue EngineeringAnti-Bacterial AgentsAntimicrobial PeptidesOxygenantimicrobial peptideMesoporous bioactive glassosteoimmunomodulatoryoxygen therapy

Identifiers

PMID40956286
PMCPMC12591200

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.