Evidence map›Paper›PMID 40956607›Full record

ArticleCurrent protocols2025

Creating an Interactive Web Interface for Networks Stored in Knowledge Graph Databases.

John Erol Evangelista, Andrew D Lutsky, Anna I Byrd, Daniel J B Clarke, Abinanda Prabhakaran, Sherry L Jenkins, Avi Ma'ayan

Abstract read
In one paragraph

Article in Current protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. The Common Fund Data Ecosystem (CFDE).bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

John Erol EvangelistaDepartment of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, New York, New York.
Andrew D LutskyDepartment of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, New York, New York.
Anna I ByrdDepartment of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, New York, New York.
Daniel J B ClarkeDepartment of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, New York, New York.
Abinanda PrabhakaranDepartment of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, New York, New York.
Sherry L JenkinsDepartment of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, New York, New York.
Avi Ma'ayanDepartment of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, New York, New York.ORCID https://orcid.org/0000-0002-6904-1017

Funding

The CFDE WorkbenchOT2OD036435 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MA'AYAN, AVI, SUBRAMANIAM, SHANKAR · 2023 to 2025
$7.2M
Proteogenomic translator for cancer biomarker discovery towards precision medicineU24CA271114 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Avi Ma'ayan, Pei Wang · 2022 to 2026
$5.0M
Elucidating the Molecular Mechanisms that Mediate DKD Progression in Patients Living with HIVR01DK131525 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI John Cijiang He, Avi Ma'ayan · 2022 to 2026
$4.2M
ARCHS4: Massive Mining of Publicly Available RNA Sequencing DataU24CA264250 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Avi Ma'ayan · 2022 to 2026
$4.1M
The LINCS DCIC Engagement Plan with the CFDEOT2OD030160 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MA'AYAN, AVI · 2020 to 2024
$3.4M
NCI NIH HHS U24 CA264250NCI NIH HHS U24 CA271114NIDDK NIH HHS R01 DK131525NIH HHS OT2 OD030160NIH HHS OT2 OD036435
6 · The paper itself

Abstract

Knowledge graphs (KG) are an emerging approach to organize biomedical research data by abstracting knowledge into networks that connect genes, diseases, pathogens, drugs, metabolites, cell types, pathways, patients, researchers, and other related concepts. While there are many KG databases, most do not offer a free and customizable web-based user interface (UI) to query and interact with KG. We developed an open-source UI to create interactive websites from data stored in KG databases. So far, the KG-UI has been applied to eight bioinformatics projects: ReproTox-KG, Enrichr-KG, Harmonizome-KG, Data Distillery KG-UI, Biomarker-KG, Common Fund Data Ecosystem Gene Set Enrichment (CFDE-GSE), ChEA-KG, and lncRNAlyzr. To demonstrate how to install and customize the KG-UI, we created a demo KG that displays a network of relationships between NIH-funded principal investigators (PIs) from a single institution in a specific year. This PI network was constructed by querying PubMed using grant information collected by the Blue Ridge Institute for Medical Research (BRIMR). After publications were collected from PubMed, PI name disambiguation and metadata formatting was performed to create the PI demo KG. Instructions for ingesting this network of PIs into a KG database, setting up the web app, and customizing the app are provided in a step-by-step user guide. The KG-UI source code is available from: https://github.com/MaayanLab/Knowledge-Graph-UI/ and the demo KG is available from: https://github.com/MaayanLab/PINetworkDemo. © 2025 The Author(s). Current Protocols published by Wiley Periodicals LLC. Basic Protocol 1: Creating the principal investigator network Basic Protocol 2: Validating the principal investigator network Basic Protocol 3: Ingesting the KG assertions into Neo4j Basic Protocol 4: Interacting with the KG via the Neo4j remote interface Basic Protocol 5: Building and customizing the KG-UI Basic Protocol 6: Interacting with the KG-UI website.

Indexed as

Computational BiologyDatabases, FactualInternetUser-Computer InterfaceHumansSoftwaredata harmonizationdata integrationdata visualizationknowledge graphstranscription factors

Identifiers

PMID40956607
PMCPMC12439869

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.