ReviewAging and disease2025
Lactylation Modification and Aging: A Molecular Link in the Life Process.
Review in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exercise-specific post-translational modification signatures: unveiling precise regulatory mechanisms of molecular exercise language and cellular adaptation.Frontiers in sports and active living · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, significant progress has been made in the research of aging and aging-related diseases. Epigenetic alterations, as an important marker of aging, are also one of the mechanisms that trigger aging. Lactylation modification, also known as lactylation, is a post-translational modification form (PTM) that uses lactate and lysine residues as substrates and belongs to an important field of epigenetic alterations. As an emerging research hotspot in recent years, it has made considerable breakthroughs in the study of human-related diseases, especially cancer. During the aging process, lactylation modification occurs in the body due to changes in lactate concentration, thereby affecting other aging mechanisms. This article reviews lactylation modification and cellular senescence, mitochondrial dysfunction, autophagy and energy metabolism, summarizes the current influence of lactylation modification on aging-related mechanisms, and makes bold predictions for future research based on the existing research differences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.