Evidence map›Paper›PMID 40957479›Full record

ArticleJournal of advanced research2026

The CPK3-mediated cytosolic-nuclear translocation of bHLH107 recruits HY5 to regulate the Cu

Yue Yu, Haoran Xia, Haifeng Liu, Xiangsong Chen, Wenchao Huang, Zhaohui Chu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Progress in Molecular Plant Science (2023-2025).Current issues in molecular biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yue YuState Key Laboratory of Hybrid Rice, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan 430072, China; Hubei Hongshan Laboratory, Wuhan University, Wuhan 430072, China.
Haoran XiaState Key Laboratory of Hybrid Rice, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Haifeng LiuCollege of Agronomy, Shandong Agricultural University, Taian 271018, China. Electronic address: hliu1987@sdau.edu.cn.
Xiangsong ChenState Key Laboratory of Hybrid Rice, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Wenchao HuangState Key Laboratory of Hybrid Rice, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Zhaohui ChuState Key Laboratory of Hybrid Rice, Hubei Provincial Research Center for Basic Biological Sciences, College of Life Sciences, Wuhan University, Wuhan 430072, China; Hubei Hongshan Laboratory, Wuhan University, Wuhan 430072, China; Ezhou Seed Technology Institute of Hubei Province, Ezhou 436043, China. Electronic address: zchu77@whu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCopper serves as a key component of plant micronutrients and copper-based antimicrobial compounds (CBACs), and it has been used to protect plants against diseases for more than 130 years. We previously revealed that low concentrations of Cu

objectivesHere, we aimed to identify the CuRE-binding transcription factor (CuTF) and elucidate it roles in activating the Cu

methodsTo identify the CuTF and its interactors, we performed DNA-pull-down and mass spectrometry and protein phosphorylation proteomics assays. Cu

resultsWe identified a CuTF of basic helix-loop-helix 107 (bHLH107) which is required for Cu

conclusionOverall, we revealed a CPK3-bHLH107-HY5 module that regulates the network of Cu

Indexed as

ArabidopsisArabidopsis ProteinsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBasic Helix-Loop-Helix ProteinsCalcium-Binding ProteinsCalcium-Calmodulin-Dependent Protein KinasesCopperCell NucleusCytosolGene Expression Regulation, PlantPlant ImmunityPseudomonas syringaeTranscription FactorsUp-RegulationArabidopsis ProteinsAT2G22300 protein, ArabidopsisBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBasic Helix-Loop-Helix ProteinsCalcium-Binding ProteinsCalcium-Calmodulin-Dependent Protein KinasesCopperTranscription FactorsbHLH transcription factorCalcium-dependent protein kinaseCopper response elementCytosolic–nuclear translocationHeavy metalsPhosphorylationPlant immunity

Identifiers

PMID40957479
PMCPMC13227174

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.