Evidence map›Paper›PMID 40957616›Full record

ArticleChannels (Austin, Tex.)2025

Sclareol and cinnarizine are non-selective inhibitors of voltage-gated Cav1.3 L-type Ca

Lucia Zanetti, Ferenc Török, Luisa Leitzbach, Holger Stark, Jörg Striessnig

Abstract read
In one paragraph

Article in Channels (Austin, Tex.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lucia ZanettiDepartment of Pharmacology and Toxicology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria.
Ferenc TörökDepartment of Pharmacology and Toxicology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria.ORCID 0009-0006-8133-5778
Luisa LeitzbachInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Duesseldorf, Germany.ORCID 0000-0003-0664-2170
Holger StarkInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Duesseldorf, Germany.ORCID 0000-0003-3336-1710
Jörg StriessnigDepartment of Pharmacology and Toxicology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-9406-7120

Funding

Marie Curie 847681
6 · The paper itself

Abstract

A growing body of preclinical evidence indicates that the inhibition of voltage-gated Cav1.3 L-type Ca

Indexed as

Calcium Channel BlockersCalcium Channels, L-TypeCinnarizineDiterpenesAnimalsDopaminergic NeuronsHEK293 CellsHumansMiceCalcium Channel BlockersCalcium Channels, L-TypeCinnarizineDiterpenescalcium channel blockerscinnarizineL-type calcium channelsParkinson’s diseasesclareol

Identifiers

PMID40957616
PMCPMC12445503

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.